Study: Bivalent Shot Max 29% Effective

[saxitoxin]

----NEW----
March 2023: New Bivalent Vax Between 0% to 29% Effective (preprint study by Cleveland Clinic researchers)

A preprint study by Cleveland Clinic researchers finds the emergency-authorized bivalent vax is 29% effective against the BA.4/5 variant, 20% effective against the BQ variant, and 0% effective against the XB variant. (To receive initial approval in non-emergency conditions, vaccines must demonstrate 50%+ efficacy.)

Among 51017 working-aged Cleveland Clinic employees, the bivalent COVID-19 vaccine was 29% effective in preventing infection while the BA.4/5 lineages were dominant, and 20% effective while the BQ lineages were. Effectiveness was not demonstrated when the XBB lineages were dominant.

https://www.medrxiv.org/content/10.1101 ... 625v5.full

-----
May 2023: mRNA Vaccines Useless After a Couple Months (Journal of the American Medical Association)

A new study by Italian researchers, published in JAMA, shows that - unless you're willing to get boostered every couple of months (and accept the compounding risks of myocarditis that increase with each new shot) - there's basically no point in getting vaccinated.

This systematic review and meta-analysis of secondary data from 40 studies found that the estimated vaccine effectiveness against both laboratory-confirmed Omicron infection and symptomatic disease was lower than 20% at 6 months from the administration of the primary vaccination cycle and less than 30% at 9 months from the administration of a booster dose.

These findings suggest that the effectiveness of COVID-19 vaccines against Omicron rapidly wanes over time.

https://jamanetwork.com/journals/jamane ... le/2804451

-------------------------

May 2023: mRNA Vaccines No Better than Placebo (Cell)

A new study by researchers at the Danish Institute of Advanced Science published in the Q1 journal Cell finds there was no statistically significant difference in COVID-19 survival rates between people who received an mRNA vaccine and those who did not. It did find a small, but still statistically significant, difference in survival rates for viral vector vaccines (I find this point surprising) such as AstraZeneca and J&J.

The differences in the effects of adenovirus-vector and mRNA vaccines on overall mortality, if true, would have a major impact on global health. If validated in additional studies, the protective non-specific effects of adenovirus-based vaccines on non-COVID-19 mortality, in addition to their effectiveness against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may represent an important advantage in vulnerable populations in which cardiovascular mortality is high.

Ironically, the rich countries in Europe and the USA have emphasized the more expensive mRNA vaccines because of slightly better short-term vaccine efficacy against COVID-19 compared to the relatively inexpensive adenovirus-vector vaccines and the detection of a rare blood clotting disorder associated with the adenovirus-vector vaccines, mainly AstraZeneca. While this decision is understandable in the short term during a situation with high COVID-19-related mortality, in the endemic situation in which COVID-19-related deaths have decreased, this decision may need to be reassessed. Otherwise, if the protective effects of adenovirus-vector vaccines on overall mortality in the RCTs reflect the reality, this could turn out to be a very costly decision, both economically and health wise.

https://www.cell.com/iscience/fulltext/S2589-0042(23)00810-6

----
April 2023: Vaxed at Risk of Vision Loss (Nature)

A new study by Taiwanese researchers published in the journal Nature looked at one of the growing list of serious long term side effects of the now largely discredited mRNA based COVID vaccines.

The cumulative incidence of retinal vascular occlusion was significantly higher in the vaccinated cohort compared to the unvaccinated cohort, 2 years and 12 weeks after vaccination. The risk of retinal vascular occlusion significantly increased during the first 2 weeks after vaccination and persisted for 12 weeks. Additionally, individuals with first and second dose of BNT162b2 and mRNA-1273 had significantly increased risk of retinal vascular occlusion 2 years following vaccination, while no disparity was detected between brand and dose of vaccines.

https://www.nature.com/articles/s41541-023-00661-7

RVO is generally untreatable.

[saxitoxin]

Turns out COVID-19 was never much of a thing at all ...

A new analysis suggests that a high percentage of people who required help from a ventilator due to a COVID-19 infection also developed secondary bacterial pneumonia. This pneumonia was responsible for a higher mortality rate than the COVID-19 infection.

So while COVID-19 may have put these patients in the hospital, it was actually an infection brought on by the use of a mechanical ventilator that was more likely to be the cause of death when this infection didn't respond to treatment.

https://www.sciencealert.com/most-covid ... -infection

[GaryDenton]

I am constantly astounded by the warped intelligence needed to make these comments.
Any look at reputable medical sources states:

Experts continue to recommend that everyone get vaccinated and stay up-to-date, regardless of whether they’ve had COVID-19 in the past. COVID-19 vaccination provides a stronger and longer duration of protection against future COVID-19 disease than recovering from natural infection alone. Individuals can get COVID-19 multiple times, especially as new strains circulate in communities.

There are no known additional risks of mRNA vaccines or lipid nanoparticles. Live attenuated viral vaccines, such as measles vaccine, induce an immune response that is similar to natural infection. mRNA vaccines, on the other hand, simply give the body instructions to produce one very specific part of a virus – in this case the so-called spike protein – to then induce an immune response. Because mRNA is broken down very quickly in the human body, to do its work it needs to be able to get into our cells, and so it is wrapped in a lipid nanoparticle. Once it gets into the cells to deliver the instructions, the mRNA breaks down very quickly. It does not get into the nucleus of the cell, or into our genes. Since the new mRNA vaccines have been administered, their safety profiles are reassuring.

Since April 2021, rare cases of myocarditis and pericarditis have been reported in adolescents and young adults (under 30 years of age) following receipt of mRNA vaccines – most often following the 2nd dose. COVID-19 vaccination reduces patients’ risk of myocarditis caused by getting infected with SARS-CoV-2 and developing COVID-19 disease. Studies have shown that the risk of myocarditis was up to 6 times higher post SARS-CoV-2 infection than post-mRNA vaccines. Post-vaccine myocarditis is milder, requiring shorter hospital stays (1-2 days) vs. myocarditis caused by SARS-CoV-2 infection which has been more severe requiring a hospital stay of 5 days on average. Pediatricians should consider myocarditis and pericarditis in adolescents or young adults with acute chest pain, shortness of breath, or palpitations and report any suspected cases post COVID-19 vaccination to VAERS. A history of myocarditis or pericarditis after a dose of an mRNA vaccine is also listed as a precaution for future doses. CDC continues to monitor the situation and has created guidance for healthcare providers.

The people who spread the false claims about the vaccines are generally the same ignorant fascists who are strong supporters of the corrupt unAmerican criminal fascist sexual predator who has enthralled the far Right the past few years. After his recent performance, anyone who still expresses support for the American crazy ex-president demagogue has disqualified themself from having rational conversations.

.

[GaryDenton]

I wonder why Saxi didn't include their conclusion?

"The current study revealed a strong correlation between vaccination with a mRNA vaccine and retinal vascular occlusion. However, we recommend that individuals without a history of severe allergic reaction to any component of the vaccine be vaccinated to protect against COVID-19, owing to the lack of definite causation between retinal vascular occlusion and vaccinations. Based on the official COVID-19 death reports, it is estimated that vaccinations have prevented 14.4 million excess COVID-19 deaths worldwide between December 2020 and December 202139. Thus, vaccination is the most effective method for preventing the spread of SARS-CoV-2.

The number of reported ophthalmic complications has remained low, and vaccine-related retinal vascular occlusion is very rare, although the number of COVID-19 vaccinations is enormous. "

[GaryDenton]

Similarly, the other study is informative but doesn't change the fact that people with severe COVID die at high rates.

A new analysis suggests that a high percentage of people who required help from a ventilator due to a COVID-19 infection also developed secondary bacterial pneumonia. This pneumonia was responsible for a higher mortality rate than the COVID-19 infection.

So? They are dead from complications brought on by COVID.

[bigtoughralf]

tbf I had an eye test in 2016 and another in 2023 and my eyesight had deteriorated between the two

[saxitoxin]

Similarly, the other study is informative but doesn't change the fact that people with severe COVID die at high rates.

A new analysis suggests that a high percentage of people who required help from a ventilator due to a COVID-19 infection also developed secondary bacterial pneumonia. This pneumonia was responsible for a higher mortality rate than the COVID-19 infection.

So? They are dead from complications brought on by COVID treatment.

fixed

[saxitoxin]

I wonder why Saxi didn't include their conclusion?

"The current study revealed a strong correlation between vaccination with a mRNA vaccine and retinal vascular occlusion. However, we recommend that individuals without a history of severe allergic reaction to any component of the vaccine be vaccinated to protect against COVID-19, owing to the lack of definite causation between retinal vascular occlusion and vaccinations. Based on the official COVID-19 death reports, it is estimated that vaccinations have prevented 14.4 million excess COVID-19 deaths worldwide between December 2020 and December 202139. Thus, vaccination is the most effective method for preventing the spread of SARS-CoV-2.

The number of reported ophthalmic complications has remained low, and vaccine-related retinal vascular occlusion is very rare, although the number of COVID-19 vaccinations is enormous. "

Because it's a boilerplate that's stamped onto all these studies. We have study after study showing increasingly dire consequences of the vaccine and each of them tack on this requisite sentence to the end that reads almost identically across papers, without which they won't pass desk review. No EIC wants to be labeled an anti-science extremist by Big Pharma's noise machine.

When the British Medical Journal - the world's second leading peer reviewed medical journal - published a still unrefuted chronicle that showed data integrity issues by Pfizer, the authors and editorial board were absolutely savaged. There was no refutation of the facts, merely an avalanche of personal attacks and wild accusations with no aim other than to destroy careers. Prior to the pandemic this was a well-known tactic in Big Pharma's playbook and has been endlessly chronicled.

[saxitoxin]

May 2023: mRNA Vaccines No Better than Placebo (Cell)

A new study by researchers at the Danish Institute of Advanced Science published in the Q1 journal Cell finds there was no statistically significant difference in overall mortality between people who received an mRNA vaccine and those who did not. It did find a small, but still statistically significant, difference in survival rates for viral vector vaccines (I find this point surprising) such as AstraZeneca and J&J.

The differences in the effects of adenovirus-vector and mRNA vaccines on overall mortality, if true, would have a major impact on global health. If validated in additional studies, the protective non-specific effects of adenovirus-based vaccines on non-COVID-19 mortality, in addition to their effectiveness against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may represent an important advantage in vulnerable populations in which cardiovascular mortality is high.

Ironically, the rich countries in Europe and the USA have emphasized the more expensive mRNA vaccines because of slightly better short-term vaccine efficacy against COVID-19 compared to the relatively inexpensive adenovirus-vector vaccines and the detection of a rare blood clotting disorder associated with the adenovirus-vector vaccines, mainly AstraZeneca. While this decision is understandable in the short term during a situation with high COVID-19-related mortality, in the endemic situation in which COVID-19-related deaths have decreased, this decision may need to be reassessed. Otherwise, if the protective effects of adenovirus-vector vaccines on overall mortality in the RCTs reflect the reality, this could turn out to be a very costly decision, both economically and health wise.

https://www.cell.com/iscience/fulltext/S2589-0042(23)00810-6

---

May 2023: mRNA Vaccines Useless After a Few Months (Journal of the American Medical Association)

A new study by Italian researchers, published in JAMA, shows that - unless you're willing to get boostered every couple of months (and accept the compounding risks of myocarditis that increase with each new shot) - there's basically no point in getting vaccinated.

This systematic review and meta-analysis of secondary data from 40 studies found that the estimated vaccine effectiveness against both laboratory-confirmed Omicron infection and symptomatic disease was lower than 20% at 6 months from the administration of the primary vaccination cycle and less than 30% at 9 months from the administration of a booster dose.

These findings suggest that the effectiveness of COVID-19 vaccines against Omicron rapidly wanes over time.

https://jamanetwork.com/journals/jamane ... le/2804451

---

March 2023: New Bivalent Vax Between 0% to 29% Effective (preprint study by Cleveland Clinic researchers)

A preprint study by Cleveland Clinic researchers finds the emergency-authorized bivalent vax is 29% effective against the BA.4/5 variant, 20% effective against the BQ variant, and 0% effective against the XB variant. (To receive initial approval in non-emergency conditions, vaccines must demonstrate 50%+ efficacy.)

Among 51017 working-aged Cleveland Clinic employees, the bivalent COVID-19 vaccine was 29% effective in preventing infection while the BA.4/5 lineages were dominant, and 20% effective while the BQ lineages were. Effectiveness was not demonstrated when the XBB lineages were dominant.

https://www.medrxiv.org/content/10.1101 ... 625v5.full

[saxitoxin]

Also, loved this from the Cleveland Clinic study! Curious if it'll make it into the final paper after peer review:

The risk of COVID-19 also varied by the number of COVID-19 vaccine doses previously received. The higher the number of vaccines previously received, the higher the risk of contracting COVID-19 (Figure 2).